Early vasomotor menopausal symptoms linked to increased CVD mortality Women who had vasomotor symptoms early in midlife and presented with signs and symptoms suggestive of myocardial ischemia were at a greater risk of dying due to cardiovascular disease than women in whom the menopausal symptoms occurred later, says a new study from the University of Pittsburgh School of Medicine in the United States. The WISE (Women's Ischemia Syndrome Evaluation) of the National Heart, Lung, and Blood Institute (NHLBI) recruited 254 women older than 50 years, postmenopausal, with both ovaries, not on HRT who had been referred for coronary angiography for suspected myocardial ischemia. Mortality due to cardiovascular disease was higher in women in whom vasomotor symptoms developed early compared to those who never had vasomotor symptoms. Early onset of vasomotor symptoms in these women was also associated with endothelial dysfunction with lower flow-mediated dilation (FMD) compared to women with later onset symptoms. The findings of the study are published September 26, 2016 in the journal Menopause.